Makhalova G.O., Mikhailova E.A., Kshnyaseva S.K., Konstantinova O.D., Zherebyatyeva O.O., Fomina M.V., Pervushina L.A., Aznabaeva L.M., Kirgizova S.B., Lyashenko I.E.
HYPOBARIC HYPOXYTHERAPY AS THE FACTOR OF THE REGULATION OF MICROECOLOGICAL VIOLATIONS OF THE UROGENITAL BIOTOPE AT NONCARRYING OF PREGNANCY PREGNANCY NOT INCUBATION ^{[№ 8 ' 2017]}
In the clinical medicine, various methods of the hypoxic system are widely used as a non-medicament means of correction of the functional state. The study included the biological material of 90 women planning a pregnancy. The authors evaluated the effect of hypobaric hypoxic therapy in complex pregravid preparation for the normalization of cytokine levels in the cervical discharge in women with habitual miscarriages of the fetus. Concentrations of IL-1β and γ-IFN were performed using the solid-phase ELISA method, using reagent kits from Cytokine (St. Petersburg, Russia). Hypobaric treatment is carried out in the Russian medical vacuum unit-the Ural-1 pressure chamber. In women, before the planned pregnancy, the level of IL-1β averaged (40.7 ± 2.8) pg/ml, the concentration of INF-γ was (46.0 ± 2.3) pg/ml. Comparative evaluation with healthy indices revealed that these values exceed the lessons of the test markers in healthy women. In patients treated under the conditions of a pressure chamber, indications, in comparison with the initial, the content of proinflammatory cytokines, namely IL-1β, was determined on average in a concentration of (17.9 ± 2.8) pg/ml. As for changes in the concentration of INF-γ, its level significantly decreased after hypobarotherapy and amounted to (6.1 ± 1.3) pg/ml. Based on the results of the work, the authors worked out a method for hypobaric hypoxic therapy, suitable for treating this group of patients. The essence of the technique is that the inclusion in the complex pregravid preparation of 22 GPG sessions for 2 hours daily may be expedient, since it leads to a level of proinflammatory cytokine levels, bringing them closer to the level of healthy women.

Kvan O.V., Konstantinova Yu.A., Alyokhina G.P., Bykov A.V.
INFLUENCE OF PROBIOTIC PREPARATIONS ON BLOOD HEMATOLOGIC PARAMETERS OF LABORATORY ANIMALS ^{[№ 6 ' 2017]}
Recently, researchers in the world have become interested in symbiotic microorganisms and probiotic drugs based on them. As a result of numerous studies in this field, more and more new probiotic supplements are being created. And proceeding from these data, the goal of this study was formulated: to study the effect of strains of symbiont microflora on the hematological indices of the blood of laboratory animals. The work is aimed at studying the influence of probiotic drugs (sporobacterin, soybean-bifidum) on morphological and biochemical indicators of blood of laboratory animals of the Wistar line. Studies of the morphological parameters of the blood of experimental animals showed that the level of leukocytes in the first test group (sporobacterin) significantly exceeded the control n, in the second experimental group (soya-bifidum), a significant decrease in the index was observed. Of all the morphological parameters, significant changes were characterized by hemoglobin and platelets in the first experimental group. Thus, the hemoglobin level of the first test group significantly exceeded control. The content of platelets in the first test group also significantly exceeded the control group in two, in the second test group the content was within the normal range. Considering the biochemical indicators of the blood of experimental animals, it should be pointed out that the level of amylase and creatinine in the second experimental group significantly decreases with respect to control. On the parameters of the total protein, the changes were insignificant. The urea index in the second test group increased significantly, relative to control. The index of glucose content relative to the control group in both the first test group and in the second group decreased. The level of total cholesterol throughout the period was relatively stable and is close to the control values. Thus, the inclusion of probiotic drugs in the diet of animals improves carbohydrate and lipid metabolism. In the course of experimental studies, soybean bifidum has a positive effect on blood counts, and the administration of sporobacterin leads to an increase in the content of leukocytes, hemoglobin and platelets, which indicates the occurrence of an inflammatory process in the body of experimental animals.

Mikhailova E.A., Konstantinova O.D., Kshnyasev S.K., Fomin V.M., Zherebyateva O.O., Kalinina L.A., Mahalova G.O., Faizullina E.K.
SOME OF THE TECHNIQUES AND THE WAYS TO ENHANCE COGNITIVE ACTIVITY OF STUDENTS MEDICAL SCHOOL ^{[№ 1 ' 2016]}
Realization of fgos of new generation aimed at the inclusion of more techniques and training methods that stimulate creativity of both teachers and learners, paying particular attention to feedback. This is especially true for medical schools. In all fields of knowledge are rapidly increasing the amount of information that must be adapted to broadcast to the students and to evaluate its assimilation in a limited number of teaching hours allotted to the discipline. From this point of view, the application of programmed learning, in particular the control of mastering of knowledge, is very appropriate and justified. The use of carefully designed learning programs and algorithms with a rigid sequence of controlling influences is not in doubt. In practical sessions the teacher is able to diagnose the level of student to the lesson. Such methods allow control over certain sections of the course. The learning process of medical school is designed so that a student, mastering knowledge of the cycles of biomedical Sciences, clinical disciplines, mastering the methods and techniques of General and private medical thinking, diagnostic techniques. Therefore, the learning process aims at developing the learner qualities required of clinical thinking, the development of its activity. Targeted and tailored exposure to a teacher and textbooks, ultimately, should lead to the development and promote self-development of the student. Along with this, the deepening of knowledge, development of elements of creativity, professional and communicative skills, are best implemented when the organization of the collective work. Collective learning is characterized by the activity of all, cooperation in problem solving and collaborative discussion. In this case, each member of the team has the opportunity to act as teachers or in the role of the learner. In the practice of teacher didactic tasks discussed our directions become more specific forms and purposes: for example, to enable the student to recognize by external signs some causes of disease, to analyze data describing the condition of the patient, read X-rays, an electrocardiogram, to analyze blood, urine, feces, perform palpation, to sew up the wound, etc.

Chepasov V.I., Konstantinova O.D.
FORECAST OF DELIVERY TIME ON TIDAL GRAVITY CHANGES ^{[№ 4 ' 2011]}
The application of factor and spectral analysis to find the basic parameters that are used as parameters-arguments in the parametric model prediction is considered in this work. The results of the forecast, carried out on models constructed using the least squares method and method of D. Brandon.