Klimova T.A., Barysheva E.S., Morozova N.V., Korobova I.V.
APPLICATION OF PROBIOTIC PREPARATIONS BASED ON BACILLUS OF THE GENUS BACILLUS IN THE IRON AND ZINC SYSTEM OF DELIVERY IN THE ORGANISM OF LABORATORY ANIMALS ^{[№ 9 ' 2017]}
Studies in the field of iron and zinc deficiency are caused by the high prevalence of iron deficiency and deficient zinc states according to official statistics of the Ministry of Health of the Russian Federation. It is known that metals in comparison with other elements have the ability to bioaccumulate. Microorganisms are able to extract and concentrate metals, in particular, this ability is possessed by microorganisms that are part of probiotic preparations based on bacteria of the genus Bacillus.
The results of the study of the possibility of delivering iron and zinc to the organism of laboratory animals using probiotic preparations based on bacteria of the genus Bacillus are presented. The probiotic strains were the living and inactivated bacteria of the genus Bacillus: B. subtilis 534, B. cereus 5832, B. licheniformis 7038 and B. subtilis 7048. The data obtained indicate that in the iron delivery system, the most effective probiotic strains studied are inactivated with B. licheniformis 7038 and B. subtilis 7048 (increase in iron in the skin of laboratory animals by 31.7 %, in bone tissue — 80.8 %, in muscle tissue — 75.9 %). In the zinc delivery system, the B. subtilis strain 534 proved to be the most effective, while the zinc content in the skin of laboratory animals increased by 60 %, in bone tissue by 78.5 %, and in muscle tissue by 43.6 %.
In the iron delivery system, the most effective of the drugs being tested is “Vetom-2”, and the least “Sporobacterin”. In the zinc delivery system, the most effective is “Sporobacterin”, and the least effective is “Bactisubtil”.

Klimova T.A., Barysheva E.S., Sizentsov A.N.
ESTIMATION OF THE EFFECT OF ANIONIC IRON COMPONENTS ON BIOTOXICITY WITH RESPECT TO PROBIOTIC STRAINS ^{[№ 8 ' 2017]}
Metals have the ability to bioaccumulate. Microorganisms can extract and concentrate metals. This ability is possessed by microorganisms that are part of probiotic preparations, in particular bacteria of the genus Bacillus. It is very important that the microorganisms of the genus Bacillus, which are part of probiotic preparations, are self-antagonizing antagonists. Bacteria of the genus Bacillus, which are part of probiotic preparations, can exert an antitoxic effect, which manifests itself in the active excretion of toxic substances from the body, as well as heavy metals. The purpose of our work was to study the effect of anionic iron components on the biotoxicity of probiotic strains. Probiotic strains included probiotic preparations: B. subtilis 534, B. cereus 5832, B. subtilis 10641, B. amyloliquefaciens 10642, B. amyloliquefaciens 10643. The data obtained indicate a significant biotoxicity of anionic iron components with respect to probiotic strains . The most sensitive were the action of the anionic components of ferric chloride III. B. cereus 5832 and B. amyloliquefaciens 10642, when exposed to the anionic components of iron (II) nitrate B. subtilis 10641, when exposed to the anionic components of iron (II) sulfate B. amyloliquefaciens 10642. It was also found that high concentrations of anionic iron components have a significant toxic effect on all probiotic strains studied, which is due to the anionic component and, as a consequence, the level of dissociation of the molecules of the test compounds.

Gorelov S.N., Klimov, M.I.
ALGORITHM SEARCH OF OPTIMAL CONSTRUCTION VARIANT BY METHOD OF LOCAL LAGRANGE MULTIPLIERS VARIATIONS ^{[№ 9 ' 2013]}
The paper deals with the aspects of efficient algorithm construction for optimal projecting of structures. The investigation with the appliance of generalized Lagrange methods resulted in the construction of algorithm which does not require the convexity of functions, and more over, the uninterrupted multitude of permissible points. The method under investigation has a number of advantages regarding calculating, that is the replacement of a conventional problem by an un conventional one and the possibility of its complex use in combination with some other methods of an absolute optimization.

Klimov A.V., Berdinskiy V.L.
MAGNETIC STATES OF BUILDING BLOCKS OF THREE-NUCLEAR MOLECULAR ANTIFERROMAGNETS. ^{[№ 4 ' 2012]}
The ground magnetic and spin states of triangular hetero-ionic complexes [M'(M")₂]L₃ containing ions M' and M" with different electron spins have been studied. These ions are supposed to interact via exchange interactions with negative exchange constants J and J'. Noncoplanar magnetic and spin structures are possible. Spin functions are independent of J'/J. The ratio J'/J affects only realization of one of the possible spin states. Such complexes with noncoplanar magnetic structures can be used for designing 2D and 3D lattices of new molecular ferrimagnets.

Klimova T.V.
WORLD PRACTICES OF CRITICAL THINKING FORMING ^{[№ 2 ' 2012]}
The paper describes practices of critical thinking development and practical tasks that can be used to create the ability to assess knowledge and realize the difference between knowing terms and understanding their meaning.

Klimova T.V.
EVALUATION OF TEACHING CONDITIONS OF CRITICAL THINKING OF STUDENTS (ON THE EXAMPLE OF NATURAL SPECIALTIES OF OSU) ^{[№ 1 ' 2012]}
The article describes experimental work on the formation of students' critical thinking, methods of organization of training with the use of technology for the development of critical thinking through reading and writing and its interpretation in natural science disciplines, methods and forms of implementation of the pedagogical conditions.

Klimov V.V.
VALUE SELF-DETERMINATION OF A PERSONALITY: DIFFICULTIES AND CONTRADICTIONS… ^{[№ 7 ' 2007]}
The base of value self-determination of a personality is a complicated, dynamic, managed system of interdependent elements, which includes different levels and forms of interaction of social and individual features in a personality, definite forms of internal and external interaction, specific forms of environment understanding by a personality, presence and future, and also the essence of a person’s own "I".

Albakasov A.I., Klimov M.I.
TO THE PROBLEM OF SLIT-LIKE DISCONTINUITY FLAW REGULATION IN CONSTRUCTIONS WITH WATER CONTENT MEDIUM ^{[№ 9 ' 2006]}
The task solution of well-founded norms establishment on defects of presser and gas-oil-pipe line vessels working in conditions of aggressive mediums is put in the forefront in this article. Development of slit defects in construction material is forecasted as with methods of destruction mechanics as the theory of elasticity with computer modeling. Appraisals of marginal state of concrete constructions (pipe lines, devices) were received with accounting of defects development peculiarities. Giving in article numeral analysis of development of lengthy defects (flat and stepped slits) allows perfecting corresponding normative documents.

Pankratovich T.M., Klimova T.E.
PROBLEM-TECHNOLOGICAL APPROACH TO THE COMMUNICATIVE WORK DEVELOPMENT OF PHYSICAL TRAINING TEACHER ^{[№ 9 ' 2006]}
Containing characteristics of communicative creativeness as a leading feature in the structure of communicative competence of physical training teacher are regarded in this article. The approach of communicative creativeness development of physical training teacher is proved here and methodological mechanisms of its realization at the process of communicative preparation of physical training teacher are suggested.

Mayko O.Y., Popova L.V., Klimova O.L., Leontjeva N.P.
SYNOVITIS ULTRASONIC DIAGNOSTICS OF THE PATIENTS SUFFERING FORM GONARTHROSIS ^{[№ 7 ' 2004]}
Diagnostic possibilities of arthrosonography (ASG) for synovitis and periarthritis diagnostics of the patients suffering form gonarthrosis of I-III stages were defined during the investigation of 40 patients suffering from gonarthrosis in acute stage. Clinical investigations showed that arthrosonography is a quite informative method of synovitis and periarthritis diagnostics including subclinical one and helps to enlarge data on rontgenologic diagnostics of gonarthrosis of I-III stage. Key words: gonarthosis, arthrosonography, synovitis.

T. A. Klimova
WORK TO IMPROVE TEACHERS` QUALIFICATION IN LENINGRAD IN THE 50-IES ^{[№ 2 ' 2001]}
The article deals with speeding up secondary school teachers in some country regions and arising advanced pedagogical experience in the middle of the 50-ies.