Miroshnichenko I.V., Lutsay E.D., Klimushkin A.V., Volodin A.V., Kalinina E.A., Boev V.A.
MODERN APPROACHES TO THE EDUCATIONAL PROCESS ORGANIZATION FOR THE FORMATION OF CANCER ALERTNESS AMONG MEDICAL WORKERS ^{[№ 3 ' 2019]}
Annual and steady increase of the population oncological morbidity is observed. In particular, for the population of the Orenburg region, the issues of malignant neoplasms early diagnosis are very relevant. In 2018, the growth rate was 4,4 %, compared with 2016. The detection rate of malignant neoplasms during preventive medical examinations amounted to 41,0 %. This indicator is higher than the Russian average. Among the number of actively detected malignant neoplasms, on the average, more than 60 % in the region was detected at the stage I — II of the disease, but there were areas where this indicator is less than 40,0 %.
The Institute of Professional Education of the Orenburg State Medical University developed the pilot project on inclusion of all categories of medical workers of the Orenburg region state medical organizations in the continuing medical education system to update knowledge on cancer alertness.
During the pilot project, we tested primary healthcare workers: therapists, general practitioners, obstetricians-gynecologists of women’s consultations. Initial level of knowledge and choice of the most preferred professional development course from the proposed ones were defined. Additional professional programs developed by the professorial and teaching staff of the University together with leading experts of the Ministry of Health of the region had the required components: distance learning, availability of simulation training. At the end of the courses, medical workers expressed general opinion about the need for such form of education organization. It allowed them to increase the level of professional competencies without leaving their workplaces. For medical workers, an important motivation factor for choosing an education trajectory became the results of the knowledge screening on cancer alertness issues.

Klimova T.A., Barysheva E.S., Morozova N.V., Korobova I.V.
APPLICATION OF PROBIOTIC PREPARATIONS BASED ON BACILLUS OF THE GENUS BACILLUS IN THE IRON AND ZINC SYSTEM OF DELIVERY IN THE ORGANISM OF LABORATORY ANIMALS ^{[№ 9 ' 2017]}
Studies in the field of iron and zinc deficiency are caused by the high prevalence of iron deficiency and deficient zinc states according to official statistics of the Ministry of Health of the Russian Federation. It is known that metals in comparison with other elements have the ability to bioaccumulate. Microorganisms are able to extract and concentrate metals, in particular, this ability is possessed by microorganisms that are part of probiotic preparations based on bacteria of the genus Bacillus.
The results of the study of the possibility of delivering iron and zinc to the organism of laboratory animals using probiotic preparations based on bacteria of the genus Bacillus are presented. The probiotic strains were the living and inactivated bacteria of the genus Bacillus: B. subtilis 534, B. cereus 5832, B. licheniformis 7038 and B. subtilis 7048. The data obtained indicate that in the iron delivery system, the most effective probiotic strains studied are inactivated with B. licheniformis 7038 and B. subtilis 7048 (increase in iron in the skin of laboratory animals by 31.7 %, in bone tissue — 80.8 %, in muscle tissue — 75.9 %). In the zinc delivery system, the B. subtilis strain 534 proved to be the most effective, while the zinc content in the skin of laboratory animals increased by 60 %, in bone tissue by 78.5 %, and in muscle tissue by 43.6 %.
In the iron delivery system, the most effective of the drugs being tested is “Vetom-2”, and the least “Sporobacterin”. In the zinc delivery system, the most effective is “Sporobacterin”, and the least effective is “Bactisubtil”.

Klimova T.A., Barysheva E.S., Sizentsov A.N.
ESTIMATION OF THE EFFECT OF ANIONIC IRON COMPONENTS ON BIOTOXICITY WITH RESPECT TO PROBIOTIC STRAINS ^{[№ 8 ' 2017]}
Metals have the ability to bioaccumulate. Microorganisms can extract and concentrate metals. This ability is possessed by microorganisms that are part of probiotic preparations, in particular bacteria of the genus Bacillus. It is very important that the microorganisms of the genus Bacillus, which are part of probiotic preparations, are self-antagonizing antagonists. Bacteria of the genus Bacillus, which are part of probiotic preparations, can exert an antitoxic effect, which manifests itself in the active excretion of toxic substances from the body, as well as heavy metals. The purpose of our work was to study the effect of anionic iron components on the biotoxicity of probiotic strains. Probiotic strains included probiotic preparations: B. subtilis 534, B. cereus 5832, B. subtilis 10641, B. amyloliquefaciens 10642, B. amyloliquefaciens 10643. The data obtained indicate a significant biotoxicity of anionic iron components with respect to probiotic strains . The most sensitive were the action of the anionic components of ferric chloride III. B. cereus 5832 and B. amyloliquefaciens 10642, when exposed to the anionic components of iron (II) nitrate B. subtilis 10641, when exposed to the anionic components of iron (II) sulfate B. amyloliquefaciens 10642. It was also found that high concentrations of anionic iron components have a significant toxic effect on all probiotic strains studied, which is due to the anionic component and, as a consequence, the level of dissociation of the molecules of the test compounds.

Kuksanov V.F., Clementyev A.I., Kuksanova E.V.
SPECIAL PROTECTION OF SOILS OF ORENBURG REGION: SCIENTIFIC AND LEGAL ASPECTS ^{[№ 1 ' 2014]}
The ecological concept and structure of the Red List of the soils, being scientific and legislative base of special protection of a soil cover and a variety is stated. For the purpose of special protection allocated soil таксонов for the Orenburg region the landscape and ecological network of especially protected soil territories is designed. Need of development of the legislative base providing certain guarantees of preservation of soils and other components of the live, lifeless nature and the biosphere, the Red List based on the status is proved. The developed concept and structure Red the book of soils of the Orenburg region lies in line with the Red List of soils of Russia.

Gorelov S.N., Klimov, M.I.
ALGORITHM SEARCH OF OPTIMAL CONSTRUCTION VARIANT BY METHOD OF LOCAL LAGRANGE MULTIPLIERS VARIATIONS ^{[№ 9 ' 2013]}
The paper deals with the aspects of efficient algorithm construction for optimal projecting of structures. The investigation with the appliance of generalized Lagrange methods resulted in the construction of algorithm which does not require the convexity of functions, and more over, the uninterrupted multitude of permissible points. The method under investigation has a number of advantages regarding calculating, that is the replacement of a conventional problem by an un conventional one and the possibility of its complex use in combination with some other methods of an absolute optimization.

Klimentova E.G.
THE EFFECT OF BACILLUS THURINGIENSIS δ-ENDOTOXIN ON THE LEVELOF PELLICLE FORMING ACTIVITY AND ADHESIVE PROPERTIESOF OPPORTUNISTIC PATHOGENIC BACTERIA ^{[№ 6 ' 2013]}
Found that the B. thuringiensis δ-endotoxin subsp. kurstaki introduced in a long time per os laboratory mice, lead to the development of dysbiosis, which is a change to the ability of microorganisms to film formation and adhesion properties of opportunistic pathogens, which creates conditions for the subsequent invasion of the host tissue and causes infections.

Klimov A.V., Berdinskiy V.L.
MAGNETIC STATES OF BUILDING BLOCKS OF THREE-NUCLEAR MOLECULAR ANTIFERROMAGNETS. ^{[№ 4 ' 2012]}
The ground magnetic and spin states of triangular hetero-ionic complexes [M'(M")₂]L₃ containing ions M' and M" with different electron spins have been studied. These ions are supposed to interact via exchange interactions with negative exchange constants J and J'. Noncoplanar magnetic and spin structures are possible. Spin functions are independent of J'/J. The ratio J'/J affects only realization of one of the possible spin states. Such complexes with noncoplanar magnetic structures can be used for designing 2D and 3D lattices of new molecular ferrimagnets.

Klimova T.V.
WORLD PRACTICES OF CRITICAL THINKING FORMING ^{[№ 2 ' 2012]}
The paper describes practices of critical thinking development and practical tasks that can be used to create the ability to assess knowledge and realize the difference between knowing terms and understanding their meaning.

Klimova T.V.
EVALUATION OF TEACHING CONDITIONS OF CRITICAL THINKING OF STUDENTS (ON THE EXAMPLE OF NATURAL SPECIALTIES OF OSU) ^{[№ 1 ' 2012]}
The article describes experimental work on the formation of students' critical thinking, methods of organization of training with the use of technology for the development of critical thinking through reading and writing and its interpretation in natural science disciplines, methods and forms of implementation of the pedagogical conditions.

Klimenkova P.O.
COMPARATIVE CHARACTERISTICS OF SOIL PHYSICAL PROPERTIES OF DIFFERENT TYPES OF CHERNOZEMS ORENBURG ^{[№ 12 ' 2011]}
Density, permeability, and maintenance of soil agronomically valuable aggregates were studied in the Orenburg region of typical chernozem, ordinary divergent slopes and southern black soils. These physical properties of black nozemah are optimal. The results showed that physical factors such as structural condition, soil density and water permeability, and typical chernozem chernozem ordinary northern slopes are much better data than the southern black soil and ordinary chernozem southern slope.

Bakaeva M.D., Klimina I.P., Kireeva N.A., Dubovik I.E.
INFLUENCE OF CONDITIONS OF CITY EСOSУSTEM ON AEROPHYTE MICROSCOPIC FUNGI OF TREE BARK ^{[№ 2 ' 2010]}
Taxonomical composition of micromycetes, living on the bark of woody plants of the city of Ufa is first considered. Comparison of fungi biota of industrial district and recreational zone of city is conducted on specific composition, length and biomass of mycelium, to frequency of met. The types of micromycetes, steady to industrial contamination are exposed.

Anilova L.V., Kuranova V.V., Klimenkova P.O.
HUMIC FORMATIONS AND HUMUS OF CHERNOZEM OF NON-CENTRAL SLOPES OF GENERAL SYRT ^{[№ 6 ' 2009]}

Dubovik I.E., Klimina I.P., Smirnova N.G.
INFLUENCE OF ANTHROPOGENIC IMPACT ON BIOLOGICAL VARIETY OF ALGAE IN SOIL AND SURFACE-AIR SPHERE ^{[№ 6 ' 2009]}

Klim I.V.
SOCIAL ASPECTS OF NEW TENDENCIES IN DEVELOPMENT OF SPECIAL ECONOMIC ZONES AS INSTITUTIONS OF INNOVATION ECONOMY ^{[№ 5 ' 2008]}
Three new tendencies in development of free economic zones as institutions of innovation economy: change of competitive advantages base, change of specific structure and zones’ transformation into innovation clusters, are regarded in this article. It is shown that social consequences of these tendencies are revealed in washing of zones’ characteristics as a special regime, regulated labor force use, in displacement of accent in attraction of investments in favor of investments of human capital, in new social-economic role of knowledge as productive forces.

Sharipova M.Yu., Dubovik I.E., Nagaeva V.Kh., Rakhmatullina I.V., Klimina I.P.
ALGOFLORA OF SPECIALLY PROTECTED TERRITORIES OF SOUTHERN URAL ^{[№ 12 ' 2007]}
The researches’ results of soil algae of Southern-Ural state nature reserve and national park "Bashkiria" are given in this article. Leading departments of algoflora of studied OOPT are revealed here. The analysis of dependence of species variety of algae and their abundance on anthropogenic loading is given in this work. At the first time ecological-taxonomic structure of algae inhabited on rind of woody plants of national park "Bashkiria" is regarded.