Vestnik On-line
Orenburg State University may 04, 2024   RU/EN
Headings of Vestnik
Pedagogics
Psychology
Other

Search
Vak
Антиплагиат
Orcid
Viniti
ЭБС Лань
Rsl
Лицензия Creative Commons

2014, № 12 (173)



Fedotova T.C., Hakkanen V.M., Trofimova S.V. PATHOGENETIC ASPECTS OF AGE-RELATED MACULAR DEGENERATION OF THE RETINA Age-related macular degeneration of the retina is currently ranked third among eye diseases that may lead to blindness. Main causes of the disease are considered to be aging of Bruch's membrane, local inflammation and oxidative stress. Due to modern research methods scientists have isolated a lot of various genes. On the one hand, mutations in these genes contribute to the development of the disease, on the other hand, they can be protective factors.Key words: age-related macular degeneration, gene, retinal pigment epithelium, Bruch's membrane.

Download
References:

1. Astakhov, Y.S. Modern methods of diagnosis of "dry" form of age-related macular degeneration / Y.S. Astakhov, A.B. Lisochkin, P.A. Nechyporenko // Oftalmol. Gazette. — 2010. — T. III, №2. — P. 41–47.

2. Boyko, E.V. Molecular genetic basis of AMD / E.V. Boyko, S.V. Churashov, T.A. Kamilova // Journal of Ophthalmology. — Volume 129. — 2013. — №2. — P. 86–90.

3. Budzinskaya, M.V. The effect of genetic mutations on clinical presentation of subretinal neovascularization. Message 2 The role of polymorphisms of genes HTRA and VEGF [Text] / M.V. Budzinskaya, T.V. Weather, I.D. Strelkova // Journal of Ophthalmology: A two-month scientific journal. — 2011. — V. 127, №4. — P. 9–16.

4. Liebman, E.S. State and dynamics of blindness and visual disability due to pathology of the vision in the Proceedings of the VII Congress Russia / E.S. Liebman, E.V. Yadav // Ophthalmologists Russia. — M., 2000 — P. 209–214.

5. Nechyporenko, P.A. "Dry" form of age-related macular degeneration: pathogenesis, classification, diagnosis. Review of the literature / P.A. Nechyporenko // Ophthalmology in Belarus. — Minsk: Polyprint, 2010. — №4. — P. 46–69.

6. Prokopeva, M.Yu. Clinico-hemodynamic criteria for predicting the course of the initial stage of age-related macular degeneration : diss. … Candidate. Med. Science / M.Yu. Prokopeva. — Chelyabinsk, 2007. — 135 p.

7. Boyko, E.V. Age-related macular degeneration (risk factors, classification, diagnosis, prevention, treatment) / E.V. Boyko, L.V. Zhuravleva, S.V. Sosnovskiy // Guidelines. — M., 2010. — 71 p.

8. Adinoyi O. Garba Bevasiranib for the Treatment of Wet, Age-Related Macular Degeneration / Adinoyi O. Garba, Shaker A. Mousa // Ophthalmology and Eye Diseases. — 2010. — 2. — P. 75–83.

9. Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration / Anand Swaroop [et al.] // Annu Rev Genomic Hum Genet. — 2009. — 10. — P. 19–43.

10. Anatomy and development of the macula: specialisation and the vulnerability to macular degeneration. — Clin Exp Optom. — 2005. — 88. — P. 269–281.

11. Case-control genetic association study of fibulin-6 (FBLN6 or HMCN1) variants in age-related macular degeneration (AMD) / S.A. Fisher [et al.] // Hum Mutat. — 2007, Apr. — 28(4). — P. 406–413.

12. Sun, C. FB/C2 gene polymorphisms and risk of age-related macular degeneration: a systematic review and meta-analysis / C. Sun, M. Zhao, X. Li // Curr Eye Res. — 2012, Apr. — 37(4) — P. 259–271.

13. Cherney E.F. The pathogenesis of vascular macular degeneration / E.F. Cherney // Thes.rep. Ophthalmological Congress "White Nights", May 28–31, 2001. — P. 3–5.

14. Decreased thickness and integrity of the macular elastic layer of Bruch's membrane correspond to the distribution of lesions associated with age-related macular degeneration / N.H. Chong [et al.] // Am J Pathol. — 2005. — 166. — P. 241–251.

15. Ciulla, T. Evolving pathophysiological paradigms for age related macular degeneration / T. Ciulla // Br О Ophthalmol. — 2001. — 85. — P. 510–512.

16. De Jong, P.T. Age-related Macular Degeneration / P.T. De Jong // The New England Journal of Medicine. — 2006. — 355(14). — Р. 1474–1485.

17. Evans, J. Is the incident of registrable age–related macular degeneration in increasing? / J. Evans, K. Wormald // Br. J. Ophthalmol. — 1996. — Vol. 80, №1. — P. 9–14.

18. Gottlieb, J.L. Age-related macular degeneration / J.L. Gottlieb // JAMA. — 2002. — №288. — P. 2233–2236.

19. Preparation of Bruch's membrane and analysis of the age-related changes in the structural collagens / W. Karwatowski [et al.] // Br J Ophthalmol. — 1995. — 79(10). — P. 944–952.

20. C.C. Klaver [et al.] // Arch Ophthalmol. — 1998. — 116. — P. 653–658.

21. Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization / C.M. Li [et al.] // Invest Ophthalmol Vis Sci. — 2005, Jul. — 46(7). — P. 2576–2586.

22. Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration / A.H. Milam [et al.] // Ophthalmology. — 2000. — 107. — P. 2256–2266.

23. Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population / I. Nakata [et al.] // Invest Ophthalmol Vis Sci. — 2012, Feb. — 16. — 53(2). — P. 794-798.

24. The role of CRP and inflammation in the pathogenesis of age-related macular degeneration / E. Colak [et al.] // Biochem Med (Zagreb). — 2012, Feb. — 22(1) — P. 39–48.


About this article

Author: Hokkanen V.M.

Year: 2014


Editor-in-chief
Sergey Aleksandrovich
MIROSHNIKOV

Crossref
Cyberleninka
Doi
Europeanlibrary
Googleacademy
scienceindex
worldcat
© Электронное периодическое издание: ВЕСТНИК ОГУ on-line (VESTNIK OSU on-line), ISSN on-line 1814-6465
Зарегистрировано в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций
Свидетельство о регистрации СМИ: Эл № ФС77-37678 от 29 сентября 2009 г.
Учредитель: Оренбургский государственный университет (ОГУ)
Главный редактор: С.А. Мирошников
Адрес редакции: 460018, г. Оренбург, проспект Победы, д. 13, к. 2335
Тел./факс: (3532)37-27-78 E-mail: vestnik@mail.osu.ru
1999–2024 © CIT OSU