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Ushakova Yu.V.
Kulagina E.P., Ushakova Yu.V., Chepasov V.I. WORKING OUT OF METHODS OF SERUM IFR-1 AND LEPTINE LEVEL DETERMINATION OF PATIENTS WITH PANCREATIC INSULAR DIABETES WITHOUT DIABETIC NEPHROPATHY ON THE BASE OF MULTIVARIATE STATISTICS METHODS In this article the authors show the method of IFR-1 and leptine indexes determination in a blood serum of children with pancreatic insular diabetes without diabetic nephropathy with help of which it is possible to set their optimal level and to distinguish the patients who are not threatened with diabetic nephropathy development. On the base of multivariate statistics method the model for IFR-1 indexes and leptine forecasting in a blood serum of patients with pancreatic insular diabetes without diabetic nephropathy and identification of group of patients with pancreatic insular diabetes without diabetic nephropathy.
Ushakova Yu.V., Kulagina E.P., Chepasov V.I. DETERMINATION OF IGF-1 AND LEPTIN IN BLOOD SERUM OF PATIENTS WITH PANCREATIC DIABETES AND DIABETIC NEPHROPATHY AND DEVELOPMENT OF METHODS FOR IDENTIFICATION OF GROUPS OF PATIENTS WITH DN Target of examination was study of level of serum IGF-1 and leptin of patients with diabetic nephropathy (DN) and development of the methods which would allow to prognose rates of IGF-1 and leptin of children with DN and identify the group of patients with unknown pathology. 24 children 3-18 years aged (average age 14,78 years{95% DN: 13,52-16,04}) have been examined. Clinico-laboratory figures, rates of concentration of IGF-1 and leptin in blood serum have been valuated. They used multivariate statistics methods (correlation analysis, factor analysis and regression analysis) to detect patterns of relationship between main rates of the examined group. As to children with DN, their serum IGF-1 concentration is determined by the age of a patient at the moment of investigation; index of interlobar renal arteries pulsation; decrease of passing rate of radiopharmaceutical through bloodstream by left kidney; time of getting maximum in left kidney. The level of serum leptin of children belonging to the investigated group is characterized by a relative insulin dose of short effect.
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Editor-in-chief |
Sergey Aleksandrovich MIROSHNIKOV |
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