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Nikonorov A.A.

2013, № 12 (161)


Tinkov A.A., Nikonorov A.A.
INFLUENCE OF IRON AND COPPER CONSUMPTION ON ADIPOGENESIS AND ATHEROGENESIS INITIATION IN WISTAR RATS
The aim of the current study was investigation of the iron and copper consumption of the adipogenic effect of the high-fat diet and development of atherogenic changes of the lipoprotein profile in Wistar rats. It has been shown that Fe2+ and Cu2+ consumption potentiates the adipogenic effect of the high-fat diet as assessed by absolute and relative adipose tissue content in the rats' organism. It has been estimated that ecologically-relevant doses of iron and copper induce atherogenic changes in the serum lipoprotein spectra in the experimental animals.
Key words: iron, copper, high-fat diet, atherogenesis, adipogenesis.

2012, № 6 (142)


Tinkov A.A., Rogachova M.N., Nikonorov A.A.
CHRONIC CONSUMPTION OF IRON AND COPPER SALTS WITH DRINKING WATER INDUCES OXIDATIVE DAMAGE OF SERUM PROTEINS AND LIPIDS
In the current experiment on female Wistar rats the influence of inorganic salts of Fe and Cu on intensity of free radical oxidation was studied. It is shown that consumption of Fe and Cu with drinking water in doses which exceed maximum permissible concentration 2– and 4-fold for three months induces free radical oxidation processes leading to cumulation of lipid peroxidation (TBARS) and protein oxidation (carbonyls and fluorescent amino acids) products. It is estimated that prooxidant action of isolated iron salts is more potent than in case of copper salts, while the combined consumption of copper and iron is more effective in inducing free radical oxidation than isolated metals.
Key words: iron, cooper, free-radical oxidation.

2009, № 12


Yakovlev, DI, Prokofiev, AB, Tinkoff AN, Nikonorov AA
HYPOLIPIDEMIC EFFECTS OF COURSE ALTITUDE CHAMBER HYPOXIA IN PATIENTS WITH MYOCARDIAL INFARCTION
The effect of adaptation to periodic pressure chamber hypoxia (APBG) on the state of lipid profile of blood serum in 45 patients with myocardial infarction (MI) in a period of healing in comparison with the physical training that was conducted on 15 patients. Found that adaptive therapy leads to a significant reduction in total cholesterol, low density lipoprotein, triglyceride and atherogenic index. Revealed that the rate APBG accompanied by significant decrease by 6,6% of arolipoproteinov A1 in the serum, the major apo of HDL.
Key words: myocardial infarction, adaptation, anoxia, cholesterol.

2007, № 12


Girina L.V., Nikonorov A.A., Prokofiev A.B., Tinkov A.N.
CHEMICAL MODIFICATION OF BLOOD APOPROTEINS OF PERSONS WITH ATHEROGENIC DISLIPOPROTEINEMIA AND ITS CORRECTION WITH PERIODICAL HYPOBARIC HYPOXIA


Editor-in-chief
Sergey Aleksandrovich
MIROSHNIKOV

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© Электронное периодическое издание: ВЕСТНИК ОГУ on-line (VESTNIK OSU on-line), ISSN on-line 1814-6465
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Учредитель: Оренбургский государственный университет (ОГУ)
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